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Light Therapy for Seasonal Affective Disorder A Review of Efficacy

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Psychotherapy and Psychosomatics

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The Efficacy of Light Therapy in the Handling of Seasonal Affective Disorder: A Meta-Analysis of Randomized Controlled Trials

Pjrek Eastward.a · Friedrich M.-E.a · Cambioli Fifty.a,b · Dold M.a · Jäger F.c · Komorowski A.a · Lanzenberger R.a · Kasper Southward.a · Winkler D.a

aDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Republic of austria
bCompetence Center for Eating Beliefs, Obesity and the Psyche, Zofingen Hospital, Zofingen, Switzerland
cAcademy Medical Center Freiburg, University of Freiburg, Freiburg, Germany

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Psychother Psychosom 2020;89:17–24

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Article / Publication Details

First-Page Preview

Abstract of Standard Research Article

Received: May 23, 2019
Accustomed: Baronial 22, 2019
Published online: October 01, 2019
Effect release date: January 2020

Number of Print Pages: eight
Number of Figures: 0
Number of Tables: 0

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional data: https://www.karger.com/PPS

Abstruse

Background: Bright light therapy (BLT) has been used as a handling for seasonal affective disorder (Pitiful) for over xxx years. This meta-assay was aimed to assess the efficacy of BLT in the treatment of Distressing in adults. Method: We performed a systematic literature search including randomized, single- or double-blind clinical trials investigating BLT (≥1,000 lx, light box or light visor) against dim calorie-free (≤400 60) or sham/low-density negative ion generators equally placebo. Just first-period data were used from crossover trials. The primary outcome was the post-treatment depression score measured past validated scales, and the secondary event was the charge per unit of response to handling. Results: A total of xix studies finally met our predefined inclusion criteria. BLT was superior over placebo with a standardized mean difference of –0.37 (95% CI: –0.63 to –0.12) for depression ratings (18 studies, 610 patients) and a gamble ratio of one.42 (95% CI: 1.08–1.85) for response to active treatment (sixteen studies, 559 patients). We establish no show for a publication bias, but moderate heterogeneity of the studies and a moderate-to-high hazard of bias. Conclusions: BLT tin can be regarded as an effective treatment for SAD, simply the available prove stems from methodologically heterogeneous studies with small-to-medium sample sizes, necessitating larger loftier-quality clinical trials.

© 2019 S. Karger AG, Basel

References

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington (DC): American Psychiatric Publishing; 2013.
  2. Rosenthal NE, Sack DA, Gillin JC, Lewy AJ, Goodwin FK, Davenport Y, et al. Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry. 1984 Jan;41(1):72–80.
  3. Levitan RD. The chronobiology and neurobiology of wintertime seasonal affective disorder. Dialogues Clin Neurosci. 2007;nine(iii):315–24.
  4. Terman M, Terman JS, Quitkin FM, McGrath PJ, Stewart JW, Rafferty B. Light therapy for seasonal affective disorder. A review of efficacy. Neuropsychopharmacology. 1989 Mar;2(ane):ane–22.
  5. Winkler D, Pjrek E, Konstantinidis A, Kasper S. Drug treatment of seasonal affective disorder. In: Partonen T, Pandi-Perumal SR, editors. Seasonal melancholia disorder: practice and research. Oxford: Oxford University Printing; 2009. pp. 281–95.
  6. Pjrek Due east, Winkler D, Stastny J, Konstantinidis A, Heiden A, Kasper Due south. Bright light therapy in seasonal affective disorder – does it suffice? Eur Neuropsychopharmacol. 2004 Aug;14(iv):347–51.
  7. Terman M, Terman JS. Light therapy for seasonal and nonseasonal depression: efficacy, protocol, safety, and side furnishings. CNS Spectr. 2005 Aug;10(eight):647–63; quiz 672.
  8. Berson DM, Dunn FA, Takao Yard. Phototransduction by retinal ganglion cells that prepare the circadian clock. Scientific discipline. 2002 February;295(5557):1070–3.
  9. Hattar Southward, Liao HW, Takao M, Berson DM, Yau KW. Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science. 2002 Feb;295(5557):1065–70.
  10. Roecklein KA, Wong PM, Miller MA, Donofry SD, Kamarck ML, Brainard GC. Melanopsin, photosensitive ganglion cells, and seasonal affective disorder. Neurosci Biobehav Rev. 2013 Mar;37(3):229–39.
  11. Michel S, Itri J, Colwell CS. Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors. J Neurophysiol. 2002 Aug;88(2):817–28.
  12. Wirz-Justice A. From the basic neuroscience of circadian clock function to low-cal therapy for depression: on the emergence of chronotherapeutics. J Affect Disord. 2009 Aug;116(3):159–sixty.
  13. Lewy AJ, Rough JN, Songer JB, Mishra N, Yuhas Thou, Emens JS. The phase shift hypothesis for the circadian component of winter depression. Dialogues Clin Neurosci. 2007;9(3):291–300.
  14. Partonen T, Vakkuri O, Lönnqvist J. Suppression of melatonin secretion by bright light in seasonal affective disorder. Biol Psychiatry. 1997 Sep;42(6):509–13.
  15. Pereira JC Jr, Pradella Hallinan M, Alves RC. Secondary to excessive melatonin synthesis, the consumption of tryptophan from outside the blood-encephalon bulwark and melatonin over-signaling in the pars tuberalis may be central to the pathophysiology of winter depression. Med Hypotheses. 2017 Jan;98:69–75.
  16. Yatham LN, Lam RW, Zis AP. Growth hormone response to sumatriptan (5-HT1D agonist) challenge in seasonal affective disorder: effects of low-cal therapy. Biol Psychiatry. 1997 Jul;42(1):24–nine.
  17. Neumeister A, Turner EH, Matthews JR, Postolache TT, Barnett RL, Rauh Chiliad, et al. Effects of tryptophan depletion vs catecholamine depletion in patients with seasonal affective disorder in remission with light therapy. Arch Gen Psychiatry. 1998 Jun;55(6):524–30.
  18. Neumeister A, Konstantinidis A, Praschak-Rieder North, Willeit M, Hilger E, Stastny J, et al. Monoaminergic function in the pathogenesis of seasonal melancholia disorder. Int J Neuropsychopharmacol. 2001 December;4(4):409–20.
  19. Harrison SJ, Tyrer AE, Levitan RD, Xu X, Houle S, Wilson AA, et al. Lite therapy and serotonin transporter binding in the anterior cingulate and prefrontal cortex. Acta Psychiatr Scand. 2015 Nov;132(5):379–88.
  20. Tyrer AE, Levitan RD, Houle Due south, Wilson AA, Nobrega JN, Rusjan PM, et al. Serotonin transporter binding is reduced in seasonal affective disorder following light therapy. Acta Psychiatr Scand. 2016 Nov;134(5):410–9.
  21. Spies Thou, James GM, Vraka C, Philippe C, Hienert M, Gryglewski G, et al. Encephalon monoamine oxidase A in seasonal affective disorder and treatment with bright light therapy. Transl Psychiatry. 2018 Sep;8(1):198.
  22. Leu SJ, Shiah IS, Yatham LN, Cheu YM, Lam RW. Allowed-inflammatory markers in patients with seasonal affective disorder: furnishings of light therapy. J Touch Disord. 2001 Mar;63(1-3):27–34.
  23. Stastny J, Konstantinidis A, Schwarz MJ, Rosenthal NE, Vitouch O, Kasper S, et al. Effects of tryptophan depletion and catecholamine depletion on immune parameters in patients with seasonal affective disorder in remission with light therapy. Biol Psychiatry. 2003 Feb;53(iv):332–7.
  24. Gilt RN, Gaynes BN, Ekstrom RD, Hamer RM, Jacobsen FM, Suppes T, et al. The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence. Am J Psychiatry. 2005 Apr;162(4):656–62.
  25. Mårtensson B, Pettersson A, Berglund 50, Ekselius 50. Vivid white light therapy in depression: a disquisitional review of the evidence. J Affect Disord. 2015 Aug;182:1–7.
  26. Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Markey SP. Light suppresses melatonin secretion in humans. Science. 1980 Dec;210(4475):1267–9.
  27. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorder. 3rd edition, revision (DSM-Iii-R). Washington, DC: American Psychiatric Printing; 1987.
  28. American Psychiatric Clan. Diagnostic and Statistical Manual of Mental Disorder. quaternary edition, text revision (DSM-Four-TR). Washington, DC, American Psychiatric Press, 2000.
  29. Kasper South, Rogers SL, Yancey A, Schulz PM, Skwerer RG, Rosenthal NE. Phototherapy in individuals with and without subsyndromal seasonal affective disorder. Arch Gen Psychiatry. 1989 Sep;46(9):837–44.
  30. Vieta E, Suppes T. Bipolar II disorder: arguments for and against a distinct diagnostic entity. Bipolar Disord. 2008 Feb;ten(1 Pt two):163–78.
  31. Roecklein KA, Rohan KJ, Postolache TT. Is seasonal affective disorder a bipolar variant? Curr Psychiatr. 2010 Feb;ix(ii):42–54.
  32. Sohn CH, Lam RW. Treatment of seasonal affective disorder: unipolar versus bipolar differences. Curr Psychiatry Rep. 2004 December;six(vi):478–85.
  33. Pail G, Huf W, Pjrek E, Winkler D, Willeit Yard, Praschak-Rieder Due north, et al. Bright-light therapy in the treatment of mood disorders. Neuropsychobiology. 2011;64(3):152–62.
  34. Schardt C, Adams MB, Owens T, Keitz S, Fontelo P. Utilization of the PICO framework to meliorate searching PubMed for clinical questions. BMC Med Inform Decis Mak. 2007 Jun;7(1):16.
  35. R Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2018. Available from: https://www.R-project.org/.
  36. Schwarzer One thousand. meta: an R parcel for meta-analysis. R News. 2007;7:forty–5.
  37. Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw. 2010;36(three):1–48.
  38. DerSimonian R, Laird Northward. Meta-analysis in clinical trials revisited. Contemp Clin Trials. 2015 November;45 Pt A:139–45.
  39. Ades AE, Lu G, Higgins JP. The estimation of random-furnishings meta-analysis in determination models. Med Decis Making. 2005 Nov-Dec;25(half-dozen):646–54.
  40. Hedges LV. Estimation of result size from a series of contained experiments. Psychol Balderdash. 1982;92(ii):490–ix.
  41. Mantel Due north, Haenszel Due west. Statistical aspects of the analysis of data from retrospective studies of affliction. J Natl Cancer Inst. 1959 April;22(4):719–48.
  42. Higgins JP, Sterne JA, Savović J, Page MJ, Hróbjartsson A, Boutron I, et al. A revised tool for assessing risk of bias in randomized trials. In: Chandler J, McKenzie J, Boutron I, Welch Five, editors. Cochrane methods. Cochrane Database Syst Rev 2016;10 (Suppl 1).
  43. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003 Sep;327(7414):557–60.
  44. Begg CB, Mazumdar Chiliad. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994 Dec;50(4):1088–101.
  45. Egger M, Davey Smith Chiliad, Schneider M, Minder C. Bias in meta-analysis detected past a simple, graphical exam. BMJ. 1997 Sep;315(7109):629–34.
  46. Bown MJ, Sutton AJ. Quality control in systematic reviews and meta-analyses. Eur J Vasc Endovasc Surg. 2010 Nov;twoscore(5):669–77.
  47. James SP, Wehr TA, Sack DA, Parry BL, Rosenthal NE. Treatment of seasonal affective disorder with low-cal in the evening. Br J Psychiatry. 1985 Oct;147(4):424–8.
  48. Nagayama H, Daimon G, Mishima K, Yamazaki J, Mizuma H, Ohta T, et al. Vivid versus dim low-cal therapy for seasonal affective disorder: a collaborative report. Jpn J Psychiatry Neurol. 1994;48:488–nine.
  49. Winton F, Corn T, Huson LW, Franey C, Arendt J, Checkley SA. Effects of light handling upon mood and melatonin in patients with seasonal melancholia disorder. Psychol Med. 1989 Aug;xix(3):585–90.
  50. Schwartz PJ, Irish potato DL, Wehr TA, Garcia-Borreguero D, Oren DA, Moul DE, et al. Effects of meta-chlorophenylpiperazine infusions in patients with seasonal affective disorder and good for you control subjects. Diurnal responses and nocturnal regulatory mechanisms. Curvation Gen Psychiatry. 1997 Apr;54(iv):375–85.
  51. Rosenthal NE, Skwerer RG, Sack DA, Duncan CC, Jacobsen FM, Tamarkin L, et al. Biological effects of morning-plus-evening bright light handling of seasonal affective disorder. Psychopharmacol Bull. 1987;23(three):364–ix.
  52. Lam RW, Buchanan A, Clark CM, Remick RA. Ultraviolet versus non-ultraviolet low-cal therapy for seasonal affective disorder. J Clin Psychiatry. 1991 May;52(5):213–six.
  53. Levitt AJ, Joffe RT, Male monarch Due east. Dim versus vivid ruddy (light-emitting diode) lite in the treatment of seasonal affective disorder. Acta Psychiatr Scand. 1994 May;89(v):341–5.
  54. Desan PH, Weinstein AJ, Michalak EE, Tam EM, Meesters Y, Ruiter MJ, et al. A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Melancholia Disorder (Pitiful). BMC Psychiatry. 2007 Aug;seven(one):38.
  55. Eastman CI, Lahmeyer HW, Watell LG, Good GD, Immature MA. A placebo-controlled trial of calorie-free handling for winter depression. J Bear upon Disord. 1992 Dec;26(4):211–21.
  56. Eastman CI, Young MA, Fogg LF, Liu L, Meaden PM. Bright light treatment of wintertime depression: a placebo-controlled trial. Arch Gen Psychiatry. 1998 October;55(ten):883–9.
  57. Terman G, Terman JS. Controlled trial of naturalistic dawn simulation and negative air ionization for seasonal affective disorder. Am J Psychiatry. 2006 December;163(12):2126–33.
  58. Terman Chiliad, Terman JS, Ross DC. A controlled trial of timed vivid light and negative air ionization for treatment of wintertime depression. Arch Gen Psychiatry. 1998 Oct;55(10):875–82.
  59. Flory R, Ametepe J, Bowers B. A randomized, placebo-controlled trial of bright calorie-free and high-density negative air ions for treatment of Seasonal Affective Disorder. Psychiatry Res. 2010 May;177(1-2):101–8.
  60. Wileman SM, Eagles JM, Andrew JE, Howie FL, Cameron IM, McCormack M, et al. Light therapy for seasonal affective disorder in master care: randomised controlled trial. Br J Psychiatry. 2001 Apr;178(4):311–6.
  61. Magnusson A, Kristbjarnarson H. Handling of seasonal affective disorder with high-intensity low-cal. A phototherapy written report with an Icelandic group of patients. J Affect Disord. 1991 Feb;21(2):141–7.
  62. Reeves GM, Nijjar GV, Langenberg P, Johnson MA, Khabazghazvini B, Sleemi A, et al. Improvement in depression scores after 1 hour of calorie-free therapy treatment in patients with seasonal melancholia disorder. J Nerv Ment Dis. 2012 Jan;200(i):51–5.
  63. Grota LJ, Yerevanian BI, Gupta Yard, Kruse J, Zborowski L. Phototherapy for seasonal major depressive disorder: effectiveness of bright calorie-free of high or depression intensity. Psychiatry Res. 1989 Jul;29(i):29–35.
  64. Wirz-Justice A, Bucheli C, Graw P, Kielholz P, Fisch HU, Woggon B. Light treatment of seasonal affective disorder in Switzerland. Acta Psychiatr Scand. 1986 Aug;74(2):193–204.
  65. Hamilton Yard. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960 February;23(1):56–62.
  66. Williams JB, Link MJ, Rosenthal NE, Amira L, Terman K. Structured Interview Guide for the Hamilton Depression Rating Scale – Seasonal Affective Disorder Version, 2002 rev. New York (NY): New York Country Psychiatric Found; 2002.
  67. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring low. Arch Gen Psychiatry. 1961 Jun;4(6):561–71.
  68. Beck AT, Steer RA, Brown GK. Transmission for the Brook Depression Inventory-II. San Antonio (TX): Psychological Corporation; 1996.
  69. Terman M, Williams JB. Cess instruments. In: Partonen T, Magnusson A, editors. Seasonal affective disorder: practice and enquiry. New York: Oxford University Press; 2001.
  70. Levitt AJ, Wesson VA, Joffe RT, Maunder RG, Rex EF. A controlled comparison of calorie-free box and head-mounted units in the treatment of seasonal depression. J Clin Psychiatry. 1996 Mar;57(3):105–10.
  71. Martinez B, Kasper Southward, Ruhrmann S, Möller HJ. Hypericum in the treatment of seasonal affective disorders. J Geriatr Psychiatry Neurol. 1994 Oct;7 Suppl 1:S29–33.
  72. Michalon Thousand, Eskes GA, Mate-Kole CC. Furnishings of light therapy on neuropsychological function and mood in seasonal melancholia disorder. J Psychiatry Neurosci. 1997 Jan;22(i):nineteen–28.
  73. Avery DH, Eder DN, Bolte MA, Hellekson CJ, Dunner DL, Vitiello MV, et al. Dawn simulation and bright low-cal in the handling of SAD: a controlled written report. Biol Psychiatry. 2001 Aug;fifty(iii):205–16.
  74. Hedges LV, Pigott TD. The ability of statistical tests for moderators in meta-analysis. Psychol Methods. 2004 December;9(four):426–45.
  75. American Psychiatric Association. Practice guideline for the treatment of patients with major depressive disorder. 3rd ed. American Psychiatric Association; 2010.
  76. Deutsche Gesellschaft für Psychiatrie und Psychotherapie (DGPPN). Leitlinie/Nationale Versorgungsleitlinie Unipolare Depression. DGPPN; 2015.
  77. Cohen J. Statistical power assay for the behavioral sciences. 2nd ed. Hillsdale, NJ, USA: Erlbaum; 1988.
  78. Arroll B, Elley CR, Fishman T, Goodyear-Smith FA, Kenealy T, Blashki G, et al. Antidepressants versus placebo for low in primary intendance. Cochrane Database Syst Rev. 2009 Jul;(three):CD007954.
  79. Gibbons RD, Hur Thousand, Brownish CH, Davis JM, Isle of mann JJ. Benefits from antidepressants: synthesis of 6-week patient-level outcomes from double-blind placebo-controlled randomized trials of fluoxetine and venlafaxine. Curvation Gen Psychiatry. 2012 Jun;69(six):572–9.
  80. Al-Karawi D, Jubair 50. Bright light therapy for nonseasonal depression: meta-analysis of clinical trials. J Impact Disord. 2016 Jul;198:64–71.
  81. Fifty-fifty C, Schröder CM, Friedman S, Rouillon F. Efficacy of light therapy in nonseasonal low: a systematic review. J Affect Disord. 2008 May;108(i-2):11–23.
  82. Jane-wit D, Horwitz RI, Concato J. Variation in results from randomized, controlled trials: stochastic or systematic? J Clin Epidemiol. 2010 Jan;63(one):56–63.
  83. Rosenthal NE, Sack DA, Carpenter CJ, Parry BL, Mendelson WB, Wehr TA. Antidepressant furnishings of lite in seasonal affective disorder. Am J Psychiatry. 1985 Feb;142(2):163–70.
  84. Botanov Y, Ilardi SS. The acute side furnishings of bright light therapy: a placebo-controlled investigation. PLoS One. 2013 Sep;8(ix):e75893.
  85. Kogan AO, Guilford PM. Side furnishings of short-term 10,000-lux light therapy. Am J Psychiatry. 1998 Feb;155(2):293–4.
  86. Labbate LA, Lafer B, Thibault A, Sachs GS. Side furnishings induced past bright light treatment for seasonal melancholia disorder. J Clin Psychiatry. 1994 May;55(5):189–91.
  87. Levitt AJ, Joffe RT, Moul DE, Lam RW, Teicher MH, Lebegue B, et al. Side furnishings of low-cal therapy in seasonal affective disorder. Am J Psychiatry. 1993 Apr;150(4):650–2.
  88. Brouwer A, Nguyen HT, Snoek FJ, van Raalte DH, Beekman AT, Moll AC, et al. Lite therapy: is information technology prophylactic for the optics? Acta Psychiatr Scand. 2017 Dec;136(6):534–48.
  89. Gallin PF, Terman 1000, Remé CE, Rafferty B, Terman JS, Burde RM. Ophthalmologic examination of patients with seasonal melancholia disorder, before and after brilliant light therapy. Am J Ophthalmol. 1995 Feb;119(2):202–10.
  90. Rosenthal NE, Sack DA, Skwerer RG, Jacobsen FM, Wehr TA. Phototherapy for seasonal affective disorder. J Biol Rhythms. 1988;iii(ii):101–xx.
  91. Eastman CI. What the placebo literature tin can tell u.s. about calorie-free therapy for SAD. Psychopharmacol Bull. 1990;26(iv):495–504.
  92. Fava GA, Guidi J, Rafanelli C, Rickels K. The clinical inadequacy of the placebo model and the development of an alternative conceptual framework. Psychother Psychosom. 2017;86(6):332–twoscore.
  93. Westrin A, Lam RW. Long-term and preventative handling for seasonal affective disorder. CNS Drugs. 2007;21(xi):901–9.
  94. Nussbaumer-Streit B, Pjrek E, Kien C, Gartlehner One thousand, Bartova L, Friedrich ME, et al. Implementing prevention of seasonal melancholia disorder from patients' and physicians' perspectives – a qualitative report. BMC Psychiatry. 2018 November;xviii(1):372.
  95. Nussbaumer-Streit B, Winkler D, Spies Yard, Kasper S, Pjrek East. Prevention of seasonal affective disorder in daily clinical practice: results of a survey in German-speaking countries. BMC Psychiatry. 2017 Jul;17(1):247.
  96. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Grouping. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009 Jul;half dozen(seven):e1000097.
  97. Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton Fifty. Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry. J Clin Epidemiol. 2008 Oct;61(10):991–half dozen.

Article / Publication Details

First-Page Preview

Abstract of Standard Research Article

Received: May 23, 2019
Accepted: August 22, 2019
Published online: October 01, 2019
Issue release date: January 2020

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: https://www.karger.com/PPS

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